Early Puberty In Girls Linked To Meat Consumption

A study suggests that girls who eat a lot of meat during childhood start their periods earlier than others.

U.K. researchers compared the diets of over 3,000 12-year-old girls.

The team found that consuming over eight portions a week of meat with girls between the ages of 3 to 7 was strongly linked with early periods.

The researchers said a meat-rich diet might prepare the body for pregnancy, triggering an earlier puberty.

The average age at which girls during the 20th Century started their periods fell fairly dramatically, although it now seems to be levelling off.

This is thought to be due to better nutrition and rising levels of obesity, which has an impact on hormones.

The team used data from a group of children in the latest study that followed them from birth.

The researchers split the girls at ages of 12 years eight months into those who had already started their periods and those who had not.

They found that when comparing their diets at the ages of three, seven and 10, meat intake at a young age increased their chances of having a period by age 12 by 75 percent.

Although this finding was independent of body weight, the study repeated previous research showing that bigger girls tend to menstruate early.

Breast cancer is linked with girls who started their period at an early age, probably because women are exposed to higher levels of estrogen over their lifetime.

However, the researchers wrote in Public Health Nutrition that there was no need for young girls to cut meat out of their diet as those with the highest meat consumption were eating a lot.

The seven-year-olds in the highest meat category were eating 12 or more portions each week, and the three-year-olds were having more than eight portions.

Dr. Imogen Rogers, study leader and senior lecturer in human nutrition at the University of Brighton, said weight could not be the only factor in girls having periods earlier as the average age had not gone down further with increasing levels of obesity.

She told BBC News: “Meat is a good source of zinc and iron, requirements for which are high during pregnancy.

“A meat-rich diet could be seen as indicating suitable nutritional conditions for a successful pregnancy.”

Dr. Ken Ong, pediatric endocrinologist at the Medical Research Council, told BBC that there had been “vast shifts” in the timing of first periods over the pas century.

He said the link with meat consumption was a “plausible” one.

“This was not related to larger body size, but rather could be due to a more direct effect of dietary protein on the body’s hormone levels.” RedOrbit

Thyroid Disease: The Hidden Epidemic

Is your thyroid making you fat? Around 27 million Americans have thyroid disease — and almost half don’t know it. Thyroid disease arises when the hormone-producing gland at the base of your throat goes out of whack, triggering weight fluctuation, tiredness, and emotional ups and downs, among other symptoms.

In Natural Solutions: Vibrant Health, Balanced Living’s March issue — on newsstands now — find the latest on which tests to request, as well as a quiz to help you determine if your thyroid might be to blame for weight gain and other symptoms.

When Mary Shomon reported being exhausted, moody, and unable to lose weight, her doctor attributed the symptoms to stress. When Shomon’s symptoms didn’t improve with diet, exercise, and plenty of shut-eye, she was diagnosed with an underactive thyroid.

“I thought, ‘What’s a thyroid?’” says Shomon, now an authority on thyroid disease and author of The Thyroid Diet, who was interviewed in Natural Solutions. “I’ve talked with people who have the same symptoms I had, and their doctors have diagnosed them with everything from mental illness to laziness.”

Because thyroid problems are often overlooked, it’s important to see an endocrinologist. And because synthetic thyroid medications don’t always provide relief, Natural Solutions offers science-backed information about these integrative therapies:

* Try ayurvedic herbs. Guggul and manjistha help detoxify the thyroid. And keep your endocrine system functioning optimally with ashwagandha, rhodiola, and ginseng.

* Sweat out thyroid-disrupting heavy metals by sitting in a sauna for up to 40 minutes a few times per week. Or add 2 cups of Epsom salts and 8 ounces of baking soda to a hot bath.

* Boost iodine levels to support thyroid health: Eat kelp, and take an iodine supplement daily. And if you’re hypothyroid, avoid eating a lot of broccoli, strawberries, and spinach, which reduce thyroid-hormone production. PR Newswire

Pecans May Help Protect Nervous System

Study suggests pecans may delay progression of motor neuron degeneration

Eating about a handful of pecans each day may play a role in protecting the nervous system, according to a new animal study published in the current issue of Current Topics in Nutraceutical Research. The study, conducted at the Center for Cellular Neurobiology at the University of Massachusetts Lowell, suggests adding pecans to your diet may delay the progression of age-related motor neuron degeneration. This may include diseases like amyotropic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease.

Researchers suggest vitamin E – a natural antioxidant found in pecans – may provide a key element to neurological protection shown in the study. Antioxidants are nutrients found in foods that help protect against cell damage, and studies have shown, can help fight diseases like Alzheimer’s, Parkinson’s, cancer and heart disease. Pecans are the most antioxidant-rich tree nut and are among the top 15 foods to contain the highest antioxidant capacity, according to the U.S. Department of Agriculture (USDA).

“These findings suggest regular consumption of pecans may provide significant nutritive and antioxidant benefits for your body,” said lead researcher Thomas B. Shea, PhD.

Dr. Shea and his research team carried out a number of laboratory studies on three groups of mice specifically bred to demonstrate severe decline in motor neuron function that are commonly used in studies of ALS. Each of the three groups was fed a control diet or one of two diets containing differing amounts of pecans ground into their food. Standard testing methods were used to determine how well the mice scored relative to motor neuron functions, both before and after they were provided with one of the three diets.

Mice provided a diet supplemented with pecans displayed a significant delay in decline in motor function compared to mice receiving no pecans. Mice eating the diet with the most pecans (0.05%) fared best. Both pecan groups fared significantly better than those whose diets contained no pecans. The result was based on how the mice performed in highly specific tests, each of which compared mice on the control diet with mice consuming pecan-enriched diets.

“Eating healthy doesn’t have to mean eating bland,” said Beth Hubrich, a registered dietitian with the National Pecan Shellers Association. “Pecans are a tasty addition to a healthy diet and scientific research continues to show they’re good for you as well.”

Eating a handful of pecans will also provide you with more than 19 vitamins and minerals, including vitamin A, folic acid, calcium, magnesium, phosphorus, zinc and several B vitamins, Hubrich said. Pecans are naturally cholesterol-free and sodium-free. redOrbit

Delay In Surgery Not Likely To Worsen Tumors In Men With Low-Risk Prostate Cancer

Johns Hopkins experts have found that men enrolled in an active surveillance program for prostate cancer that eventually needed surgery to remove their prostates fared just as well as men who opted to remove the gland immediately, except if a follow-up biopsy during surveillance showed high-grade cancer.

Active surveillance, or “watchful waiting,” is an option open to men whose tumors are considered small, low-grade and at low risk of being lethal. Given the potential complications of prostate surgery and likelihood that certain low-risk tumors do not require treatment, some men opt to enroll in active surveillance programs to monitor PSA levels and receive annual biopsies to detect cellular changes that signal a higher grade, more aggressive cancer for which treatment is recommended. Yet, according to the Johns Hopkins experts, there is concern that delaying surgery in this group until biopsy results worsen may result in cancers that are more lethal and difficult to cure.

Bruce Trock, Ph.D., associate professor at the Johns Hopkins Brady Urological Institute, and his colleagues compared the pathology results of men in an active surveillance group at Johns Hopkins who later had surgery with those who also had low-risk tumors and opted for immediate surgery.

Results initially showed that 116 active surveillance participants who had surgery were more likely to have high-grade, larger tumors than 348 men who had immediate surgery. But Trock says that these results were found only in 43 (37 percent) men in the surveillance group who were recommended for surgery because a follow-up biopsy during surveillance worsened to indicate a high-grade tumor.

“We think that these men had high-grade tumors to begin with that their initial biopsy missed, and this group may be over-represented in men who are recommended for treatment after an initial period of active surveillance,” says Trock. He adds that, in general, 15 to 25 percent of men whose initial biopsy shows a low-risk prostate tumor will actually have a high-grade cancer upon further review of the entire prostate once it is removed.

Apart from the 43 men whose pathology results worsened during surveillance, the remaining men in the surveillance group had similar pathology results at surgery to those in the immediate surgery group. “This means that most tumors are not likely to worsen during the period of active surveillance,” says Trock.

The researchers calculate that the risk of finding high-grade tumors in the entire group of 801 active surveillance patients is low — about 4.5 percent per year. PhysOrg

Dieting Can Cause Heart Disease, Cancer!

Going on a diet could increase the risk of developing potentially deadly conditions such as heart disease, diabetes and cancer, a study has found.

The study revealed that those who controlled their calorie intake produced higher levels of the harmful stress hormone cortisol and exposure to the hormone actually made some dieters put on weight, reports dailymail.co.uk.

Dieting could actually damage mental health too as many suffered increased psychological stress when they were constantly forced to count calories and monitor what they ate.

“Regardless of their success or failure (in losing weight), if future studies show that dieting increases stress and cortisol, doctors may need to rethink recommending it to their patients to improve health,” the researchers said.

“Chronic stress, in addition to promoting weight gain, has been linked with coronary heart disease, high blood pressure, diabetes and cancer. Dieting might potentially add to this stress burden and its consequences would best not be ignored,” they added.

The study, by California University in San Francisco and Minnesota University, looked at 121 women who were put on a standard three-week diet of 1,200 calories a day – around half a woman’s recommended daily amount of 2,000 calories.

Each patient was asked to provide a saliva sample before and after the study to test for cortisol levels. The results showed a significant increase in the amount of the hormone after three weeks on the programme. The Times of India

Selenium Shows No Benefit In Prevention Of Lung Cancer

Selenium, a supplement taken daily by millions in hopes of protection against cancer and a host of other diseases, has proven to be of no benefit in reducing a patient’s risk of developing lung cancer – either a recurrence or second primary malignancy, according to results of an international Phase III clinical trial.

Results from the decade-long study, initiated by the Eastern Cooperative Oncology Group, were presented today at the American Society of Clinical Oncology 2010 Annual Meeting by Daniel D. Karp, M.D., professor in the Department of Thoracic/Head and Neck Medical Oncology at The University of Texas MD Anderson Cancer Center.

“Several epidemiological and animal studies have long-suggested a link between deficiency of selenium and cancer development,” said Karp, the study’s principal investigator. “Interest and research escalated in the late 1990′s after a skin cancer and selenium study, published in 1996, found no benefit against the skin cancer, but did suggest an approximate 30 percent reduction of prostate and lung cancers. Our lung cancer research and another major study for the prevention of prostate cancer evolved from that finding.”

These large, follow-up clinical studies investigating the naturally occurring mineral, however, have since proven disappointing. In 2009, the National Cancer Institute (NCI) halted SELECT, an international study of more than 35,000 men investigating if either selenium or Vitamin E, alone or in combination, could reduce the risk of prostate cancer. Both supplements failed to show benefit.

According to the American Cancer Society, approximately 219,440 people were diagnosed with lung cancer in 2009 and 159,390 died from the disease, making it the leading cause of cancer death in both men and women. When caught as early as Stage I, and the tumor is surgically resectable, however, and can even be cured in about 80 percent of the cases. In this population, a chemoprevention agent would be desirable, as the risk of recurrence in Stage I patients after surgery accumulates by one to two percent annually. For example, a patient’s risk of developing a new cancer at 10 years is approximately 10-20 percent, said Karp.

From 2000 to 2009, the international NCI-sponsored Phase III study, enrolled 1,522 Stage I non-small cell lung cancer patients, all of whom had their tumors surgically removed and were cancer-free for at least six months post-surgery. Participants were randomized to receive either 200 micrograms of selenium or placebo. The study’s primary endpoints were reduction of development of a new cancer, or second primary, and/or recurrence of their initial cancer.

The study was halted early after an interim analysis revealed that the progression-free survival was superior in the placebo arm: 78 percent taking the placebo were alive without recurrence after five years, compared to 72 percent on selenium. A total of 216 secondary primary tumors developed, of which 84 (38.9 percent) were lung cancers. Of those taking selenium, 1.9 percent developed a second primary tumor after the first year, compared to 1.4 percent taking placebo. In total, 3.66 percent of participants in the selenium arm developed a secondary primary tumor of any type after one year, compared to 4.1 percent in the placebo group.

Side effects were minimal and no different in both groups: of those taking placebo, 38 percent had grade 1 or 2 toxicity, and 3 percent had grade 3, compared to 39 percent and 1 percent, respectively in those taking the supplement. The study was stopped by the independent Data and Safety Monitoring Committee due to futility.

The researchers did find that in a small group of the lung cancer patients who were never smoked, selenium did provide a small benefit; however, the size of the group of patients, 94, was too small to be statistically significant.

“Our results demonstrate that selenium is not an effective chemoprevention agent in an unselected group of lung cancer patients, and it’s not something we can recommend to our patients to prevent a second cancer from developing or recurring,” said Karp. “These findings also remind us that never smokers may represent a unique disease and should be an area for special consideration for research focus.

“Given our results and that of SELECT, physicians now can point to two large NCI-sponsored Phase III trials and tell patients that, at this time, the only definitive studies that have been conducted have been negative,” said Karp. Provided by University of Texas M. D. Anderson Cancer Center. PhysOrg

Study Confirms Link Between Migraines And Stroke

People who suffer migraines are about twice as likely as people without the painful headaches to suffer a stroke caused by a blood clot, a new research review finds.

The analysis, which combined the results of 21 previous studies, confirms a connection between migraines and ischemic stroke — the most common form of stroke, occurring when a clot disrupts blood flow to the brain.

Across the studies, migraine sufferers were about twice as likely to suffer an ischemic stroke as people without migraines, according to findings published in the American Journal of Medicine.

Experts are not sure why the relationship exists, and it is not yet known whether the migraines themselves directly lead to strokes in some people.

It’s likely, however, that a common underlying process contributes to both migraines and stroke risk, said Dr. Saman Nazarian, the senior researcher on the new study and an assistant professor at Johns Hopkins University School of Medicine in Baltimore.

For now, he told Reuters Health in an email, the bottom line for migraine sufferers is that they should be particularly vigilant about controlling any modifiable risk factors for stroke that they may have.

Some of those risk factors include high blood pressure, smoking and diabetes.

“The main thing I would want (people) to take away from this is that if they get migraines, they should address stroke risk factors,” Nazarian said. “They should not smoke and they should watch their blood pressure and have it treated if it is high.”

Experts also generally say that people with migraines should remember that while the headaches are linked to a relatively increased risk of stroke, the absolute risk to any one person remains fairly low.

In one recent study of 6,100 adults with migraines, for example, 2 percent reported a history of stroke, versus 1.2 percent of 5,243 adults who did not suffer from migraines.

The current findings are based on 21 international studies conducted between 1975 and 2007 and involving more than 622,000 adults with and without migraines.

Most of the studies took into account a number of factors that might help explain any connection between migraine and stroke risk — such as age, high blood pressure, diabetes, smoking habits and weight.

Even with those factors considered, migraines themselves were linked to a two-fold increase in stroke risk when Nazarian’s team combined the results of all 21 studies.

The precise cause of migraines is not fully understood, but the pain involves constriction, and then swelling, of brain blood vessels. One theory is that people with migraine may have dysfunction in the blood vessels throughout the body, which may explain the increased risk of stroke and, as some previous studies have found, heart attack.

No one yet knows whether treating and preventing migraine attacks can do anything to affect people’s risk of cardiovascular problems.

On one hand, researchers have noted, drugs that prevent migraine attacks could theoretically lower the risk of cardiovascular problems. On the other hand, certain medications might have negative effects; some anti-inflammatory painkillers have been linked to cardiovascular risks, while migraine drugs known as “ergots” tend to constrict blood vessels throughout the body.

The current study received no drug industry funding, according to Nazarian’s team, and none of the researchers reports any industry ties. msnbc